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Nat Rev Neurol 11 , 2540 (2015)

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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

Specifically, H 2 S inhibited the production of endogenous vasoconstrictors such as ET-1, ANP, and CGRP, while promoting plasma PAMP levels, leading to vasodilation and relief of PH (Li et al., 2006b)