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Vaccine development for diseases like dengue faces significant challenges, including the issue of Antibody-Dependent Enhancement (ADE), where antibodies from a previous infection may worsen a subsequent infection with a different virus type [117]

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After just two weeks of supplementing with the glutathione precursors, the subjects obtained an antioxidant status on par with a younger crowd

These studies additionally demonstrated that at the given doses, ascorbate plasma levels of over 10 mM could be sustained for several hours, and observed maximum achievable blood concentrations of up to 49 mM [13]

(Expert Opinion) Other Treatments The Panel identified the treatments reviewed below as possibly prom ising but for which insufficient evidence currently exists to support even a Conditional Recommendation for their use