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BCL-2 protein family: attractive targets for cancer therapy

DOI: 10.2337/db13-1531 Korf, K., Wodrich, H., Haschke, A., Ocampo, C., Harder, L., Gieseke, F., Pollmann, A., Dierck, K., Prall, S., Staege, H., Ma, H., Horstmann, M.A., Evans, R.M., Sternsdorf, T

Abstract The transsulfuration pathway plays a central role in the regulation of sulfur metabolism and contributes to the maintenance of cellular homeostasis

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However, some HNE molecules escape this mechanism and react with the side chains of cysteine, histidine and lysine residues in proteins (20-22)