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Species-specific differences in receptor distribution further complicate extrapolation from preclinical models to humans, and the presence of these receptors in peripheral tissues raises concerns regarding off-target uptake (Zhang et al., 2020)

It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

Further laboratory research involves examination of its effects on mitochondrial membranes, ATP synthesis and bioenergetics of cells, with further application in age-related physiology, muscle function, cardiovascular and neurodegenerative research

However, it is always advisable to conduct a patch test before full application

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