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Zapater P, Lasso de la Vega MC, Horga JF, Such J, Frances R, Esteban A, Palazon JM, Carnicer F, Pascual S, PerezMateo M

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Once internalized into tumor cells through CD44 receptor-mediated active targeting, the HA shell of PTFTH would be preliminarily disassembled by hyaluronidase (HAase) to expose the Fe-TA metal-phenolic networks (MPNs), which would further degrade in response to an acidic lysosomal environment, leading to HAase/pH dual-responsive release of Fe 3+ and PFC/TRIM37