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therefore, your body relies on supplementation

doi: 10.1212/WNL.0000000000008591 53 HeL.SiG.HuangJ.SamuelA

[4] Patients should be aware that tretinoin often causes an initial phase of skin irritation and peeling (a retinoid reaction) as the skin acclimates, and it also heightens sensitivity to sunlight, necessitating diligent sun protection during therapy