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Given the pivotal role of lactate metabolism in pulmonary inflammation, this suggests the potential clinical value of assessing ARDS severity and prognosis from a metabolic dimension (11, 77)

368,369,370 HSF2 and DLG2 can block the oligomerization of ASC by interfering with the interaction between ASC and NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the upregulation of IL-1 expression and alleviating the inflammatory response