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Similar content being viewed by others Introduction Despite substantial improvement in surgical and percutaneous revascularization techniques, myocardial infarction (MI), defined as the irreversible damage caused by severe and sustained myocardial ischemia, and the chronic heart failure (HF) which may follow, remain among the leading causes of morbidity and mortality worldwide (Moran et al

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In most Gram-negative bacteria, the TS is backed up by a glutathione-glutaredoxin (GSH) system that is also able to scavenge reactive oxygen and nitrogen species in order to maintain redox homeostasis ( Helicobacter pylori proves to be an exception to the classification rule as a GSH-independent bacterium ( Mycobacterium tuberculosis , which does not fit within the Gram classification, is TrxR-dependent and GSH-independent ( Staphylococcus spp., Streptococcus spp., Enterococcus spp., or the exceptional GSH independent bacteria H