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The brain and muscles are particularly sensitive to oxygen deprivation, which manifests as profound fatigue, weakness, and reduced physical and cognitive performance

Additionally, individuals with a B12 deficiency may experience mood changes, such as depression or irritability, as B12 plays a role in the production of neurotransmitters that regulate mood

Intramuscular (IM) injections are common for routine repletion of B levels, whereas intravenous (IV) administration might be used in emergency situations or when large doses are required quickly

TB 500: 25 mg weekly, often used systemically

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