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This variability may be attributed to curcumins limited bioavailability, as it is rapidly metabolized and excreted from the body (493, 494)

Abstract The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment

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Therefore, potential therapeutic targets for regulating ferroptosis by enzymes related to PUFA synthesis need to be studied further

J Agric Food Chem 58:22952301 Curran JE, Jowett JB, Elliott KS, Gao Y, Gluschenko K, Wang J, Azim DM, Cai G, Mahaney MC, Comuzzie AG, Dyer TD (2005) Genetic variation in selenoprotein S influences inflammatory response