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Actually, there is a long history regarding the clinical application of HDACi for epilepsy [129, 130]

[PubMed] Vargas, J.L.C., I.K

Kochunov P, Williamson DE, Lancaster J, Fox P, Cornell J, Blangero J et al

This is where supplementation might come into play, especially for individuals who may not produce sufficient amounts due to factors such as aging, stress, poor diet, or environmental toxins