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doi: 10.1002/hep.32130

Amin NB, Darekar A, Anstee QM, Wong VW, Tacke F, Vourvahis M, et al

doi: 10.1016/j.ijbiomac.2022.12.292, 10

Eventually, when telomeres become critically short, the cell enters senescence: an irreversible state of growth arrest linked to aging and disease [22]

Further studies using humanized APOE Knock-in mice showed that BBB breakdown is mediated by apoE4 through activation of a proinflammatory cyclophilin A-matrix metalloproteinase-9 pathway in pericytes that leads to neuronal uptake of multiple blood-derived neurotoxic proteins [121]