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The material here is a research-grade lyophilized peptide vial documented for in vitro laboratory use only, with no patient-directed preparation, prescription pathway, or dispensing workflow involved

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Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

ADP insensitivity, assessed by titrating ADP into samples and measuring mitochondrial responses, is when a given concentration of ADP stimulates a smaller change in mitochondrial metabolism

Neither the disulfide lipoic acid (LA) nor GSSSG worked in this manner, and thus served as reliable controls in the high-dose experiments (Figure 1e bars 47 and Figure 2c,d)