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This deficiency in MS/MS specificity can be mitigated through chromatographic separation (Minkler et al., 2015b)

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Eigen equations showed by Y1, Y2 were combined to obtain a composite disease expression score (Y 3 = |Y 1 1 | + |Y 2 2 |) where i is the variance explained by each PC (eigenvalue) that accounts for most of the variation