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The increase in fasting nitrate/nitrite was influenced primarily by eight of the fourteen subjects receiving ALCA (Figure 4), highlighting the variability in response to dietary supplementation with L-carnitine in regards to blood nitrate/nitrite, a finding we have previously noted using glycine propionyl-L-carnitine [33]

However, in obesity, excessive weight gain leads to white adipose tissue dysfunction, resulting in unregulated secretion of adipokines, including pro-inflammatory ones, fostering a chronic low-grade inflammatory state (99)

Furthermore, using both inhibitors and RNA silencing we have shown that TGR is an essential schistosome protein, and we believe that our results have validated it as a key drug target for treatment of schistosomiasis

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