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They undergo rigorous, large-scale manufacturing processes and extensive stability testing

Dong J, Xie T, Shi C, Feng G, Zhang H, Xu Z, et al

[DOI] [PubMed] [Google Scholar] 79.Moens F., Weckx S., De Vuyst L

Repeated cycles of sickling and unsickling shortens the lifespan of the damaged sickle RBCs to about 1/6th that of normal RBCs ( FIGURE 2 These events trigger a cascade of pro-inflammatory activity setting off multiple pathophysiological factors that also involve neutrophils, platelets, and vascular endothelium (Sundd et al., 2019)

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