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[8] Development of AOD9604 was halted following poor efficacy in a later 24 week trial

All hypothesis tests were two-sided, and the threshold for statistical significance was set at P 0.99) died during their stay in the ICU

One mechanism involves reducing transforming growth factor beta-1 secretion in fibroblasts

Membrane was then blotted with antibodies to either IR (Cell Signaling Technology, Danvers, MA, Cat#3025), IGF-1R (Cell Signaling Technology, Cat#9750) or -actin (Cell Signaling Technology, Cat#4970) for 1 h at room temperature, up to overnight at 4 C

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