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However, in cases of severe injury, long-term behavioral and cognitive impairments can result (Yamamoto, Levin and Prough, 2018

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Clinically, \an GCN2 inhibitor, APL-4098, has been studied in a phase 1 trial for acute myeloid leukemia (AML), where it was well tolerated and reduced AML blast counts in 5 out of 9 of the patients (141)