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On the metabolome level, the metabolites identified mainly belonged to the group of amino acids (Fig

Our findings also highlight the need to revisit the broader antioxidant landscape in redox biology

Notably, in addition to trying to block potential downstream detrimental effects, new therapies need to be designed that preserve and boost astrocytic defences and improve astrocytic homoeostasis

Belavgeni A, Meyer C, Stumpf J, Hugo C, Linkermann A

It is hydroxylated into the catechol estrogens 2-hydroxyestradiol and 4-hydroxyestradiol and into estriol (16-hydroxyestradiol), reactions which are catalyzed by cytochrome P450 enzymes predominantly in the liver, but also in various other tissues