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This dysregulation severely impairs sperm motility and acrosome reaction capacity-critical processes for successful fertilization ( 3.1.2.2 G-protein coupled receptor pathway suppression EEDs systematically suppress GPCR-mediated signaling cascades essential for steroidogenesis and germ cell proliferation

During this study by Wang et al

Homeobox (HHEX) gene, one of the earliest foregut markers, can induce the production of downstream transcription factors HHEX and Forkhead Box A2 (FOXA2), promoting foregut fate and future liver development (34)

A., Ferrucci, L., Rosano, C., de Rekeneire, N., Houston, D

However, these peptide therapies require injections and are associated with adverse effects such as bone resorption 129