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Although it is not clear if DHEA modulates bioenergetic pathways in immune cells, it has been shown to attenuate LPS-induced production of pro-inflammatory mediators in murine RAW 264.7 macrophages (210)

Key symptoms include fatigue, pallor, shortness of breath, neurological manifestations such as paraesthesia (pins and needles), balance problems, memory difficulties, glossitis (sore red tongue), and mood changes

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Nevertheless, NACs attractive clinical characteristics (it is inexpensive, is available without a prescription, and is extremely well tolerated), as well as the animal literature indicating that it can attenuate compulsive drug-related behaviors (Kalivas, 2009), have motivated considerable interest in the agent