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Reason for initiation of KD in patients with a mitochondrial disease is intractable epilepsy and similar positive effects on epilepsy compared to patients without a primary mitochondrial disease (105)

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Cell invasion is commonly observed during processes like cancer metastasis, which is considered a specialized form of cell migration [2]

L-carnitine is believed to undergo an additional step of conversion to -butyrobetaine

The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (McConnell et al., 2015) (Figure 1)