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It can shape a profoundly immunosuppressive TME by inducing the expansion of myeloid cells, enhancing the suppressive function of Tregs, or directly driving CD8 + T cells toward terminal exhaustion, thereby undermining the efficacy of various immunotherapies [292,293,294,295,296]

Cagrilintide Based on 3 publication(s) in Google Scholar Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist

This, in turn, enhances the drug efficacy while reducing the risk of systemic toxicity, as it helps prevent rapid burst release and minimizes the need for repeated dosing (Natarajan et al., 2014

Tada, Y., Nakaya, R., Goto, S., Yamashita, Y

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