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Leveraging the acidic milieu in OA, researchers introduce acid sensitive groups (amino, carboxyl, thiol) or protonatable and acid labile linkages (esters, Schiff bases, vinyl ethers) into drug loaded matrices to achieve condition triggered degradation and precise, on demand release of anti-inflammatory agents (Ding et al., 2022)

In contrast, in prostate cancer, cuproptosis-induced upregulation of DLAT inhibits autophagy through the mTOR pathway (Wen et al., 2023)

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(101), showed a reduced clinical response in Holstein cows experimentally intramammary infected with E