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The term "hypolipidemic agents", as used herein, refer to substances other than PPAR agonist and fibrates that lower the lipid low density lipoproteins (LDL) and/or increase the high density lipoprotein (HDL) in blood

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This minimally invasive method allows the therapeutic ingredients to reach directly into the deeper layers of the skin, where melanin production takes place and thus ensures the best possible absorption and effectiveness

Of note, colistin has been shown to exert tremendous side effects causing renal and neurological toxicity with higher cumulative doses, therefore limiting its effective in vivo application (131)