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Neuroblastoma cell lines were, after ovarian cancer cell lines, the second most dependent on GPX4 (Extended Data Fig

Certain supplements such as TUDCA or fish oil may be beneficial

The glycerol phosphate pathway starts with the reaction of G-3-P with fatty acid-coenzyme A (FA-CoA) to form lysophosphatidic acid (LPA) catalyzed by glycerol-3-phosphate acyltransferase (GPAT) [44]

Routine testing of vitamin B12 levels in metformin-treated patients should be considered. Because metformin often causes digestive tract upset, many patients are also put on a proton pump inhibitor (PPIs) such as esomeprazole ( Nexium ), lansoprazole ( Prevacid ) or omeprazole ( Prilosec )

These can be purchased at your local pharmacy