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Transferrin receptor 1-targeted polymersomes therapy for colorectal cancer

The cytoprotective role of the Keap1-Nrf2 pathway

This stress can initiate some catastrophic events in the cells such as lipid peroxidation, formation of DNA adducts, protein crosslinks, and the reduction of endogenous antioxidant levels in the liver 6

Thus, the acetyl content in acetyl-L-carnitine leads to a higher bioavailability and it can be absorbed more easily

Genetic and metabolic studies have further shown that metabolites such as succinate and fumarate, which are generated under normal physiological conditions, are associated with tumorigenesis in several cancer types