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(Mondal et al., 2018) demonstrated that elevated homocysteine levels can directly modulate lipid metabolism and induce hyperlipidemia in rats through Hcy administration (50 mg/kg/d)

Homocysteine is a marker for metabolic syndrome and atherosclerosis

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect

While hGH affects glucose tolerance and insulin sensitivity, AOD9604 showed no adverse effects

J Am Chem Soc