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Mechanisms, pathways, benefits (table-like summary): GLP-1: mechanism is GLP-1 receptor agonism

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Notably, the abundance of Megasphaera was also dramatically increased in HFD-induced rats after transplantation of fecal microbiota from HFD-T monkeys and this increasing trend was consistent with that in monkeys

Intriguingly, MOTS-c behaves like an exercise mimetic in muscle: it is an exercise-induced peptide, meaning that during physical activity the levels of MOTS-c naturally rise