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Pattern recognition receptors (PRRs) on the surfaces of these cells recognize pathogen-associated molecular patterns (PAMPs) present in the invaders and, as a result, activate intracellular signaling cascades, leading to the induction of a general pro-inflammatory response 1

Conradt M, Stoffel W (1997)

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Enhanced NK cell activity and a Th1-skewed cytokine profile (marked by elevated IFN- levels) could theoretically heighten the risk of immune overactivation, which is particularly worrisome in individuals with pre-existing autoimmune disorders, where such stimulation may aggravate disease progression [151, 152]

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