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Journal of Clinical Oncology, 23(6), 1289-1294

OGrady, T

CD19+ malignancies were the first cancers to be eliminated by CAR-engineered human T cells administered intravenously to mice (7)

The cell membrane was genetically edited to highly express macrophage signal regulatory protein (MSIRP), which enhanced binding to CD47 on CRC cell surfaces, blocked the dont eat me signal, and promoted macrophage phagocytosis