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All animal handling procedures were carried out in strict accordance with the Animal Welfare guidelines approved by the Institutional Ethics Committee and Research Advisory Committee of the Mashhad University of Medical Sciences, Iran (code: IR.MUMS.PHARMACY.REC.1400.010)

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23 , 24 To function effectively, it requires large amounts of oxygen in the tumor microenvironment (TME), which is unfortunately hypoxic

6 Conclusion Current evidence indicates that Curcuma longa and its bioactive compounds may offer potential benefits in alleviating symptoms of depression and anxiety in patients with chronic diseases, particularly those with metabolic dysfunction-associated conditions (DACD)

Data visualization and additional computational analyses were performed with several R packages, including ggplot2 for graphical representation, survival for survival analyses, and corrgram for correlation visualizations [1]