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Triptolide treatment significantly suppresses PD-L1 expression in oral squamous cell carcinoma and NSCLC, modulating the immune checkpoint response and effectively inhibiting tumor growth in PDTX models and an IFN- -modulated environment, while its combination with IFN- in locoregional treatment enhances antitumor immunity in triple negative breast cancer by reversing IFN- -induced PD-L1 expression and activating cytotoxic CD8 + T lymphocytes, resulting in synergistic tumor growth inhibition [982,983,984]

For example, plasma EV proteins have been shown to correlate with CSF biomarkers, brain imaging changes, and cognitive scores in early-onset mild cognitive impairment (a prodromal stage of AD) [84]

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Azathioprine and prednisone combination therapy in refractory celiac disease