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Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction

In animal models of muscle injury, TB-500-treated tissues demonstrate less fibrosis, better vascularization, and superior biomechanical properties compared to untreated controls

1 H NMR (400 MHz, DMSO) 8.72 (s, 1H), 8.25 (s, 1H), 8.02 (d, J = 8.3 Hz, 1H), 7.46 (d, J = 6.5 Hz, 9H), 7.14 (dd, J = 7.3, 2.5 Hz, 6H), 7.08 (s, 1H), 6.94 (t, J = 5.7 Hz, 1H), 6.75 (t, J = 5.8 Hz, 1H), 4.71 (s, 1H), 4.13 (td, J = 8.2, 5.2 Hz, 1H), 3.52 (d, J = 5.7 Hz, 2H), 3.07 (d, J = 14.8 Hz, 1H), 2.85 (dd, J = 16.6, 8.5 Hz, 3H), 1.35 (s, 24H)

In human SH-SY5Y neuroblastoma cells, a well-established model for studying neuronal behavior, Epitalon significantly increased the secretion of soluble amyloid precursor protein (sAPP) by ~20%