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Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Not a peptide CHEMICAL STRUCTURE Molecular Formula : C 10 H 11 N 2 + Source: PubChem Mechanism of Action 5-Amino-1MQ acts as a highly selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), blocking the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl methionine (SAM) as a methyl donor

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AHK-Cu has also been studied for its potential involvement in anti-inflammatory signaling and angiogenesis modulation