pancreatic cancer glutathione enhancement Novel drug therapy kills cells by reducing levels of antioxidants Frontiers | Integrated Analysis of

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GPX4 catalyzes the reduction of lipid peroxides through selenocysteine (Sec) in its active center, as follows: LOOH+2GSHGPX4LOH+GSSG+H2O LOOH+2GSHGPX4LOH+GSSG+H2O The selenol group (-SeH) of selenocysteine is directly involved in electron transfer and is 100 times more catalytically efficient than regular cysteine (170)

Cytokine-targeted therapy focuses on IL- 1, employing neutralizing antibodies or receptor antagonists to block its signaling pathway, which helps alleviate inflammatory responses and preserve blood-brain barrier integrity (206)

Cell lines were procured form ATCC and included HCT116 (CCL-247), Ca Ski (CRL-1550), SJSA-1 (CRL-2098), A549(CCL-185), Hep G2 (HB-8065), MCF-7 (HTB-22), LoVo (CCL-229), SW48 (CCL-231), SW480(CCL-228), AsPC-1(CRL-1682), HL-60 (CCL-240), LS123 (CCL-255), MDA-MB-361 (HTB-27), MIA PaCa-2 (CRL-1420), HeLa (CCL-2), MS571 (HTB-34), SiHa (HTB-35), NCI-H1299 (CRL-5803), and Saos-2 (HTB-85)

Caffeine was used as an internal standard