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Scientific Reports, 9 , 12338

50 BMPR2 dysfunction causes impaired mitochondrial metabolism and other abnormalities in PH Bmpr2 mutations have been demonstrated to sufficiently cause metabolic dysfunction, which is involved in the development of PAH

33 Bic, Z., Blix, G

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Current Research Limitations Most clinical studies on GHK-Cu involve: Topical formulations In vitro research Animal models Systemic (non-injectable) delivery There is insufficient evidence in peer-reviewed literature to support: standardized injection techniques validated injectable dosing regimens long-term safety or efficacy data for injectable use As a result, clinicians should approach injectable discussions with caution and rely on evidence-based peptide education rather than anecdotal protocols