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Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions

7.3 Targeting FSP1/CoQ 10 pathway Intrastriatal administration of CoQ 10 showed higher efficacy in exerting neuroprotective effects than oral CoQ 10 delivery in a rat PD model, requiring 17,000 times lower dose (241)

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In addition to eukaryotic microorganisms such as yeast, mammalian tissue cell culture may also be used to produce the polypeptides of the present invention (see Winnacker, 1987), which is incorporated herein by reference)

In the brain, regular moderate-intensity running exercise (13 m/min 50 min/day, 2 weeks) induces myokine IL-6, which elevates hypothalamic expression of MOTS-c/-END in proopiomelanocortin (POMC) neurons [148]