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It is the combination of this SIRS response leading to leaky capillaries and cerebral vasodilation as well as the accumulation of toxins, notably ammonia, that is hypothesized to lead to cerebral edema in these patients

[DOI] [PubMed] [Google Scholar] 104.Moattari M., Moattari F., Kouchesfahani H.M., Kaka G., Sadraie S.H., Naghdi M., Mansouri K

FDA approval of tisagenlecleucel: promise and complexities of a $475 000 cancer drug