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This involved Guanine nucleotide exchange factors (GEFs) for the regulation of Rho GTPase activity such as the dedicator of cytokinesis proteins DOCK4, DOCK6, and DOCK10, suggesting a central role of the DOCK protein family which was already shown for DOCK2 in a genomewide association study (GWAS) in patients with severe cases of COVID19 (Namkoong et al , 2022)

Within the TME, all DC subpopulations may be present, albeit with phenotypes and functions that differ from those in healthy tissues

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From this, we can conclude that hypoxia is a causative agent of rheumatoid arthritis and a target for treatment