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Abstract Introduction: Motivation is a key driver in achieving goals and performing daily tasks, involving costbenefit valuations of the amount of effort required for a particular reward and can be influenced by socio-environmental factors and neurological conditions that may impact the brain reward circuitry

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the combination of PLC, niacin and l-ARG was demonstrated to significantly improve total and single items of IIEF-6 [15], whereas combined PLC and acetyl-L-carnitine (ALC) was demonstrated to significantly improve penile erectile function together with mood, being more effective than testosterone, in particular, in improving IIEF-6 score and nocturnal penile tumescence in aging men with clinical symptoms of androgen decline [24]

Although recent advances in the study of Mn biology have revolutionized our understanding of its physiological roles, several critical knowledge gaps remain

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