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Atp7b / mice recapitulate the main features of WD including accumulation of copper in the liver and extensive liver damage, which manifest in hepatitis, fibrosis, and the formation of cholangiocarcinoma 32

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Within 20 h he was hospitalized with fever, cough, frothy sputum, cyanosis, and acute respiratory failure

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10.1126/science.1168750 Science 19 AllorgeD.ChevalierD.Lo-GuidiceJ