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In clinical practice, the use of pharmacologic doses of glucocorticoids is associated with sleep disturbance

Reducing the secretion of IL6 in elderly, either by (a) administration of sex steroids, (b) decreasing fat through diet and exercise, (c) improving nighttime sleep, and (d) controlling adequately chronic pain and inflammation with nonsteroidal antiinflammatory agents, may improve sleep, daytime alertness, and performance, and decrease the risk of common ailments of old age, e.g., metabolic and cardiovascular problems, cognitive disorders, and osteoporosis (118, 149, 150)

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The changes in gene transcription led to changes in the synthesis of proteins that affect various physiological processes, including metabolism, development, and growth