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Statistical analysis was performed using an ordinary one-way ANOVA with Tukeys correction for multiple testing ( d ), two-tailed unpaired t- tests ( j, k, l and m ), compared to empty vector controls, or the two-sided Gehan-Breslow-Wilcoxon test compared to dgSHL ( a ) or between vehicle and aprotinin treatment ( c ), or for each Plgrkt overexpression construct compared to empty vector controls ( d )