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Normally when this process takes place, methionine receives a return methyl group from vitamin B12 or folic acid

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Notably, caspase-3 activation was equivalent in WT and XKR8 KO BMNs, as demonstrated by caspase-3 substrate cleavage assays (CellEvent), flow cytometric analysis of cleaved caspase-3, and immunoblotting for cleaved caspase-3 fragments (p17/p20) (Fig

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But no drug is found to be effective under in vivo conditions with a smaller number of side effects