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10.1016/j.tiv.2007.08.010 147 PasquelF

Diabetes 65 , 23312341 (2016)

However, a key limitation remains in achieving efficient and uniform CRISPR/Cas9-based transduction within intact 3D organoid structures

Although this competitive phenomenon has not yet been observed in the brain, it may be a significant reason for the poor efficacy and side effects of many therapeutic approaches, warranting further investigation

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