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Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis

doi: 10.3389/fnut.2025.1679494 Received 04 August 2025 Revised 19 October 2025 Accepted 25 December 2025 Published 22 January 2026 Volume 12 - 2025 Edited by Manuela Machado, Escola Superior de Biotecnologia - Universidade Catlica Portuguesa, Portugal Reviewed by Ivan oa, University of Rijeka, Croatia Moumita Saha, Yale University, United States Updates Copyright 2026 Chang, Lin, Renn, Liu, Yen, Liao, Tikhonova, Amstislavskaya, Singh and Chen

Furthermore, histopathological analysis has verified that this dose accurately reproduces the dermal damage characteristic of superficial second-degree burns [22], thereby establishing it as an optimal model for assessing the therapeutic efficacy of POPS extract in the treatment of severe skin injuries

elegans Argonautes, small RNAs, and pathways have been carried out, relatively little is known regarding the conservation, divergence, or function of these pathways in other nematodes 8,40,41

Increased heme oxygenase-1 (HO-1), a product of the Nrf2 target gene, inhibits adhesion molecules such as E-selectin and vascular cell adhesion molecule-1 (VCAM-1) expressed in endothelial cells via NF-B downregulation (139)