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The ratio of Dihexa to inulin in the blood was used to correct for any blood contamination in brain regions, while higher ratios in brain regions compared to blood indicated active concentration

The authors noted that human research remains limited to small pilot studies, and that no major adverse effects have been reported in published animal or early human work

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96 Additionally, AMPK activation by reduced ATP levels maintains NADPH through inhibiting NADPH consumption in fatty-acid synthesis and enhancing NADPH production from fatty-acid oxidation instead of PPP to inhibit cell death