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Booth CH, Mutkus L, Bussard K, Spaeth E, Andreeeff M, Marini FC

Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects

Dec 2009;22(4):262-265

By modulating many pathways (such as p53, FOXO, Nrf2, NF-B), among other things, it can participate in the control of oxidative stress, inflammatory reactions, apoptosis, and the breakdown of energy

Thus, combination with BSO, cisplatin and TMZ turned out to be an extremely powerful approach to improve cytotoxicity in glioma, thus providing an exciting alternative for glioma treatment