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Conclusions Compared with primary tumor, PDX models have obvious difference in metabolomic level

SZ: Investigation, Writing review & editing, Methodology, Validation

Ferroptosis scoring for CD8+ T cells and subsequent cell communication analysis revealed stronger interactions between CD8+ T cells with higher ferroptosis scores and other immune cells through IFN-II and CCL signaling, further intensifying the activation of the inflammatory microenvironment

Autophagy activators such as rapamycin, metformin and ibuprofen play a critical role in reducing seizure frequency and severity and could be adjuvant treatments in the management of epilepsy

BMSC-derived exosomal miR-144-5p preserves GCs viability, maintains follicular integrity, and prevents follicular atresia, thereby facilitating ovarian regeneration and restoring fertility